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PRIMARY HLH

IFN
γ
in primary HLH

Nonclinical data suggest that the cytokine IFNγ plays a pivotal role in the pathogenesis of primary HLH. A massive overexpression of IFNγ leads directly to downstream hypercytokinemia.1,3,4

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About Gamifant

HOw Gamifant WOrks

Gamifant binds to soluble and receptor-bound forms of IFNγ. Binding to IFNγ neutralizes its activity, blocking its intracellular signaling to inhibit macrophage activation and the downstream release of proinflammatory cytokines.1,5-7

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DOsing

Dosing & Administration

Depending on patient response, Gamifant can be incrementally titrated upward or downward. Similarly, the concomitant dose of dexamethasone may be tapered from the original starting dose according to the judgment of the treating physician.1

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(95% CI: 0.42, 0.81;  P = 0.013)

discover The data

Gamifant yielded a 63% overall response rate (ORR) in patients with refractory, recurrent,or progressive disease or who were intolerant of conventional treatment. Seventy percent of patients proceeded to transplant.1

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