- - - - - - -
You are about to be redirected to a site intended for people with primary HLH or their caregivers.
You are being redirected to a third party website.
Sobi takes no responsibility for the content of this website.
Gamifant is available in 10 mg/2 mL, 50 mg/10 mL, and 100 mg/20 mL vials. Please note that vials are single use only. Any remaining drug must be discarded.
Depending on the patient’s weight and dose, the diluted sterile concentrate can be administered in a syringe or 0.9% sodium chloride for injection, USP, infusion bag.
|Infusion solution volume||Administer in|
|≤16 mL||20 mL syringe|
|>16 mL and ≤56 mL||60 mL syringe|
|≤80 mL||100 mL infusion bag|
|>80 mL and ≤230 mL||250 mL infusion bag|
|>230 mL||One 500 mL infusion bag or two 250 mL bags|
Note: Do not use with ethylene oxide–sterilized syringes.
Remove Gamifant from the refrigerator and inspect vials for particulate matter and discoloration. Gamifant should be clear to slightly opalescent, and colorless to slightly yellow. Do not use if it is discolored or if foreign particulate matter is present.
Withdraw the necessary amount of Gamifant solution and dilute with 0.9% sodium chloride injection, USP, to a maximum concentration of 2.5 mg/mL. Do not dilute product to less than 0.25 mg/mL.
Discard any unused portion left in the vial(s). Gamifant vials are for single use only.
Place the diluted solution in a syringe or infusion bag.
Gently invert the infusion bag or syringe several times to ensure complete and homogeneous distribution of Gamifant.
DO NOT SHAKE
Once the infusion solution is prepared, it should clearly be labeled for administration to the patient.
Primary hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory condition that mostly affects children, but can also occur in adults and teenagers.3-6
Gamifant reduces the inflammatory symptoms of primary HLH by neutralizing IFNγ.1
Gamifant is given as an intravenous infusion twice per week until the patient no longer requires therapy for the treatment of HLH or until hematopoietic stem cell transplantation (HSCT) is performed.1
Download the Start Form now or contact Gamifant Patient Services at 833-597-6530.