Gamifant® (emapalumab-lzsg) is a
twice-weekly infusion1

Gamifant is administered by intravenous infusion over 1 hour twice a week (every 3 to 4 days) until HSCT is performed. Gamifant should be given concomitantly with dexamethasone at a starting daily dose (for the steroid) of at least 5 to 10 mg/m2.


Dosing &

The Gamifant dosing and administration guide

Download a printable version of the dosing and administration guide for step-by-step instructions on how to optimally prepare and administer Gamifant.

Gamifant offers flexibility of dosing1

Gamifant can be incrementally titrated upward or downward according the clinician's assessment of patient response.

After the patient’s clinical condition is stabilized, decrease the dose to the previous level to maintain clinical response until HSCT.

Dexamethasone can also be tapered according to the judgment of the treating physician.


Response criteria for dose increase1

Gamifant can be increased after 3 days, based on the clinician’s assessment of unsatisfactory improvement in clinical condition, AND at least one of the following:

Fever Persistence or recurrence
Platelet Count
  • If baseline < 50,000/mm3 and no improvement to > 50,000/mm3
  • If baseline > 50,000/mm3 and < 30% improvement
  • If baseline > 100,000/mm3 and decrease to < 100,000/mm3
Neutrophil Count
  • If baseline < 500/mm3 and no improvement to > 500/mm3
  • If baseline > 500 -1000/mm3 and decrease to < 500/mm3
  • If baseline 1000-1500/mm3 and decrease to < 1000/mm3
  • If baseline ≥ 3000 ng/mL and < 20% decrease
  • If baseline < 3000 ng/mL and any increase to > 3000 ng/mL
Splenomegaly Any worsening
Coagulopathy Both D-Dimer and fibrinogen must apply
  • D-Dimer: if abnormal at baseline and no improvement
  • Fibrinogen (mg/dL): if baseline levels ≤ 100 mg/dL and no improvement or if baseline levels > 100 mg/dL and any decrease to <100 mg/dL
dosing & Administration guide