Gamifant is administered by intravenous infusion over 1 hour twice a week (every 3 to 4 days) until HSCT is performed. Gamifant should be given concomitantly with dexamethasone at a starting daily dose (for the steroid) of at least 5 to 10 mg/m2.
Gamifant can be incrementally titrated upward or downward according the clinician's assessment of patient response.
After the patient’s clinical condition is stabilized, decrease the dose to the previous level to maintain clinical response until HSCT.
Dexamethasone can also be tapered according to the judgment of the treating physician.
Gamifant can be increased after 3 days, based on the clinician’s assessment of unsatisfactory improvement in clinical condition, AND at least one of the following:
|Fever||Persistence or recurrence|
Both D-Dimer and fibrinogen must apply
Primary hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory condition that mostly affects children, but can also occur in adults and teenagers.1,4
Gamifant reduces the inflammatory symptoms of primary HLH by neutralizing IFNγ.1
Gamifant is given as an intravenous infusion twice a week until hematopoietic stem cell transplantation (HSCT) is performed.1
Gamifant can be ordered through our specialty pharmacy or one of our specialty distributors.